Rheum emodi (Rhubarb) root powder accelerates dermal wound healing by up regulating the expression of Ccr1, EGF, K6 and EGR-1

Abstract

The present study was conducted to investigate the effect of Rheum emodi (Rhubarb) root powder on the expression of wound healing genes Ccr1, EGF, Keratin 6 and EGR-1 in rabbits of different age groups. The wounds treated with Rhubarb powder showed enhanced expression of Ccr1, EGF, K6 and EGR-1 by using reverse transcription polymerase chain reaction against normal saline treated wounds in all the groups. The expression was more pronounced in group A and B treated wounds as against group C treated wounds. The Rheum emodi (Rhubarb) root powder demonstrated wound healing activity by enhancing the expression of Ccr1, EGF, K6 and EGR-1thereby confirming the therapeutic potential of Rheum emodi.