Development of polyherbal anti acne gel formulation

Abstract

Acne is the multifactorial chronic inflammatory disease of pilosebaceous gland. Propionibacterium acnes (P. acne) is considered as the major skin bacteria that causes the inflammation. The objectives of this study was to design a product to treat acne with herbal actives as herbal remedies are effective in treatment of various ailments with few or no adverse effects. Acne treatment is not only based on antimicrobial activity but also anti-oxidant, anti-inflammatory properties by which drug inhibit neutrophil migration and generation of Reactive Oxidative Species (ROS). For this purpose one essential oil and two herbal extract having anti-acne and anti-microbial properties were selected. These were incorporated into the gel base and in vitro antibacterial activities were studied against P. acne using agar diffusion method. All the formulations showed satisfactory antibacterial activity with. It was subjected for stress testing for 3months at different temperature. Thus it was concluded that formulated herbal anti acne gel can be effectively used for acne treatment.