Disposition kinetics of ivermectin (Ivomec super®) following single dose subcutaneous administration in sheep

Abstract

The present study was undertaken to evaluate the pharmacokinetics of Ivermectin (Ivomec super®) 0.2 mg/kg b.wt in Sheep. The study was conducted in four adult, indigenous male muzzafarnagari sheep (1.5- 2.5 yrs in age, weighing 23±2 kg). The plasma concentration of ivermectin was determined by HPLC. The decay in plasma concentration of drug was biexponential in sheep. The Cmax value of 17.68 ng/ml was obtained at Tmax of 3.3 days in sheep, following SC administration of Ivomec super®. The elimination half life (β_HL), volume of distribution (V1_F) and AUC were calculated as 6.84 days, 4.174 L.kg-1, 163.2 day.ng/mL in sheep , following SC administration of Ivomec super®. A dosage regimen of 0.2 mg/kg at 7 days interval is recommended in sheep.