Synthesis and radical scavenging evaluation of 4-(3-(2-hydroxyphenyl)-4, 5-dihydro-1H-pyrazol-5-yl)-2-methoxyphenol

Abstract

Sodium impregnated on activated chicken eggshells (Na-ACE) has been utilized as an eco-friendly and green catalyst for the synthesis of a pyrazoline derivative, 4-(3-(2-hydroxyphenyl)-4, 5-dihydro-1H-pyrazol-5-yl)-2-methoxyphenol via chalcone intermediate. The highest yield of chalcone (65%) was obtained from the reaction with 25% wt. catalyst at 60 oC for 8h. Meanwhile, the best yield of pyrazoline (54%) was isolated from the reaction with 20% wt. catalyst at 60 oC for 4h reaction time. The structure of organic compounds was confirmed using FT-IR, UV-Vis and LC-MS. In free radical scavenging evaluation, pyrazoline derivative exhibit antiradical activity with IC50 value of 20.45 μg/ml.