Determination of tin in trityl candesartan by flame atomic absorption spectrophotometry (AAS)

Abstract

Trityl Candesartan, a benzimidazole derivative, is an angiotensin II receptor antagonist. Angiotensin-II is a substance produced in the body that causes blood vessels to tighten. It blocks the action of angiotensin-II and therefore relaxes blood vessels and helps lower blood pressure. One major concern in the preparation process is the usage of tin (Sn) compounds, specifically tributyl tin oxide, which can cause harm to both human and environmental health. In this study, Atomic Absorption Spectrophotometry (AAS) was used for accurate determination of tin in Trityl Candesartan. The study of Sn in Trityl Candesartan found the tin content to be within the limit of 10 mg/Kg, with a correlation coefficient (R2) of 0.9997, average percent recovery (%R) of 96.5%, and relative percentage difference (%RPD) 0f 3.37%.