Protective effect of ENervin on diabetic neuropathic condition in Schwann cells

Abstract

Treatment of Diabetic Neuropathy depends on three main approaches: risk factor management and intensive glycaemic control and symptomatic pain management. It’s a type of nerve damage caused by long-term high blood sugar levels. ENervin is a polyherbal formulation very effective to rejuvenate nervous system and used for the therapy of Diabetic Neuropathy. Thus, a preliminary study has been planned to observe and evaluate the effect of ENervin on diabetic neuropathy. The ENervin tablet shows the presence of five important compounds like ar-tumerone, stigmasterol, gingerol, lupeol and trilaurin which was confirmed by HPLC analysis. In this experiment, different concentrations of ENervin decreased the Schwann cells in diabetic condition and its beneficial action was compared with Pregabalin, an oral capsule used to treat neuropathic pain. Future preclinical and clinical research of ENervin may help us to strongly support the usage of this polyherbal medicine for the treatment of pain in diabetic neuropathy.