Study the molecular docking for established phytochemicals of Cissus quadrangularis against tumor necrosis factor alpha (TNF-α) for the prevention of inflammation of arthritis as a major risk of urinary incontinence

Abstract

Cissus quadrangularis is a medicinal plant. It has been used for the treatment of inflammation related diseases. The local name of Cissus quadrangularis is harbhanga. This plant are used in all over the countries medicinally due to their potent anti-inflammatory and free radical scavenging properties. Tumor necrosis factor or TNF-α is a pro inflammatory cytokine protein, which increases during inflammation and causes pain related diseases. Different non-steroidal anti-inflammatory drugs that has been used for pain relief but this drugs have adverse side effects. For this reason researchers are showing interest for medicinal plants or Phytomedicine without any adverse side effects. The main aim of this work was to know the inhibitory activity by observing binding affinity and energy value of TNF-α towards different phytochemicals present in Cissus quadrangularis through the molecular docking study.