Evaluation of carrageenan induced anti-inflammatory activity of methanolic extract of Mollugo cerviana in albino wistar rats

Abstract

Inflammation induced by carrageenan is acute, non-immune, well-researched, and highly reproducible. The anti-inflammatory activity of test compounds by examining their ability to reduce or prevent the development of carrageenan-induced paw swelling is one of the important studies. In the present study attempts are made to validate the anti-inflammatory activity of Methanolic extract of Mollugo cerviana. The anti-inflammatory activity of the Methanolic extract of Mollugo cerviana was evaluated by carrageenan-induced rat paw oedema method. The number of migrating leukocytes in the exudates was determined. The Methanolic extract of Mollugo cerviana reduced the edema induced by carrageenan by 55.48% and 57.62% on oral administration of 100 and 200 mg/kg, as compared to the untreated control group. Animals treated with the Methanolic extract of Mollugo cerviana and standard produced a leukocyte migration of 0.55±0.06×103, 0.51±0.05x103 and 0.47±0.04×103 cells/ml, respectively. The pleurisy model showed that the Methanolic extract of Mollugo cerviana behaves as an inhibitor of leukocyte migration and the formation of pleural exudates.