Comparative pharmacokinetics of Ofloxacin following single intravenous and oral administration in goat

Abstract

Pharmacokinetic (PK) behaviour of ofloxacin following single intravenous (iv) and oral administration in goat was evaluated. Ofloxacin was administered @ 5 mg/kg body weight by iv and oral route. Plasma concentration of ofloxacin at pre-scheduled times were processed and estimated by using HPLC. The PK parameters were determined by non-compartmental open model. The therapeutic concentration was achieved in 2.5 min and 45 min and maintained up to 36 h and 8 h following iv and oral administration respectively. The mean AUC, AUMC, t1/2, MRT, Cl and Vd are 58.94 ± 19.43 μg h/ml, 1539.57 ± 724.69 μg h2/ml, 15.58 ± 1.87 h, 22.46 ± 2.71 h, 135.60 ± 31.12 ml/h/kg and 2.85 ± 0.74 L/kg respectively following iv administration. The calculated AUC, AUMC, t1/2 ka, MRT after oral administration was 11.41 ± 1.13 m/h/ml, 221.11 ± 38.44 mg/h/ml, 5.404 ± 0.78 h, 16.04 ± 1.19 h. The kinetic behaviour following iv administration is suggestive of entero-hepatic recycling with a secondary peak at 24 h. Following oral administration, ofloxacin showed poor absorption and slow elimination with mean bioavailability of 24.14 ± 1.70 % and tmax of 5.16 ± 0.72 h.