Haemato-biochemical alterations in induced acute glyphosate (C3H8NO5P) intoxication in KuroilerTM birds

Abstract

Present investigation was undertaken to analyse haemato-biochemical alterations of acute glyphosate toxicity in kuroiler birds which are at great risk to herbicide exposure. Total 60 birds were divided into two major groups (I and II). Group I was treated with LD50 of glyphosate orally for single dose. Group II served as control. Blood samples were assayed for haematological and biochemical changes. Haemogobin, Total Erythrocyte Count, Total Leucocyte Count, Packed Cell Volume increased significantly in group I. Mean Corpuscular Volume and Mean Corpuscular Haemoglobin decreased and Mean Corpuscular Haemoglobin Concentration increased in group I. Heterophil and thrombocyte count increased while lymphocyte decreased significantly in group I. Serum Alanine Aminotranferase, Aspertate transaminase, Gamma Glutamyl Transferase, Lactate Dehydrogenase and creatinine values increased. Acetyle Cholinesterase did not show any variation. Serum Total protein, albumin and globulin decreased. The results indicated that acute glyphosate intoxication produce changes in haematological and biochemical constituents in treated birds.