Cardio protective efficacy of fisetin on glycoprotein and membrane bound enzymes against isoproterenol induced cardiotoxicity in wistar rats

Abstract

This study evaluates the preventive effect of fisetin on membrane bound ATP ases and glycoprotein in isoproterenol induced myocardial infarcted rats. Male wistar rats were pretreated with fisetin (30 mg/kg) orally daily for the period of 30 days. After pretreatment, rats were subcutaneously induced myocardial infarction by isoproterenol (100 mg/kg) at an interval of 24 h for 2 days. The activity of sodium potassium adenosine triphosphatase was decreased and the activities of magnesium adenosine triphosphatase and calcium adenosine triphosphatase were increased in isoproterenol treated rats. The levels of glycoprotein (hexose, hexosamine, fucose and sialic acid) were significantly increased in serum and heart of Isoproterenol-induced rats. Pretreatment with fisetin to isoproterenol treated rats normalized all the biochemical parameters studied. The observed effects are due to their free radical membrane stabilizing property and their strong antioxidant effect.