Kinetic hydrolysis of 2,6-di-propylaniline phosphate ester in Buffer medium

Abstract

Kinetic study of the hydrolysis of 2,6-di-propylaniline phosphate ester has been investigated in pH 0.00 to 7.46 at 97±0.50C in dioxane-water medium 40% (v/v). The pH log rate profile has maximum at pH 4.17. Hydrolysis of di-ester carried out in buffer solution shows that the neutral and mononegative species are reactive in the range of pH 0.00 to 2.20 and only mononegative species in the range of pH 2.20 to 7.46. The theoretical rate determined from specific rates and fractions of the neutral and mononegative species agree closely with the experimental rates. Biomolecular nature of hydrolytic reaction has been supported on the basis of temperature and solvent effect study. The 2,6-di- propylaniline phosphate ester involves P-N bond fission, which is strengthened by isokinetic relationship. Probable reaction mechanism has been proposed for the hydrolysis of 2,6-di-propylaniline phosphate ester with neutral and mononegative species.