Microbiological Quality Investigation of Eye and Ear Ointments Available in Bangladesh

Abstract

With a previous observation of the microbial load in the ear and eye medicaments in sterile dosage forms, present investigation further incremented the microbiological condition along with anti-bacterial traits of ointment products used for the treatment of eye and ear infections. Fifteen (15) different types of eye and ear ointments manufactured in different pharmaceutical industries were assessed to demonstrate and quantify the microbiological propagation using cultural and biochemical methods. The in vitro anti-bacterial activity was also examined employing the agar well diffusion method. Almost all the samples were found to harbor bacteria while in 3 samples the bacterial bio-burden exceeded the United States Pharmacopeia (USP) or British Pharmacopeia (BP) limit (