Ameliorative effect of hydro-ethanolic extract of Tinospora cordifolia against methotrexate induced toxicity in mice

Abstract

Present study conducted on ameliorative effect of Tinospora Cordifolia against Methotrexate induced toxicity in mice on the thirty-two either sex mice having 4-5 weeks of age with approximately 20-30 gm body weight or divided into four equal groups. During experiment, mice showed dullness, depression, lethargy and loss of decreased spontaneous activity and body weight like clinical sign and symptoms. Significant decreased in body weight, body weight gain, feed consumption and significantly increased in relative organ weight of liver were recorded in methotrexatetreated group. Hematological finding revealed significant decreased (P≤ 0.05) in Hb, PCV, TEC, TLC and lymphocyte count were also observed in methotrexate treatedgroup. The mild to moderate intensive lesions were observed in clinical sign, organ weight and hematological findings in Tinospora cordifolia treated group. It was revealed that supplementation of hydro-ethanolic extract of Tinospora cordifolia through oral route may reduce the severity of methotrexate toxicity in mice.