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New approach to skin burn treatment: Potential of secretome from wharton’s jelly mesenchymal stem cell therapy

Sukmawati Tansil TanYohanes FirmansyahJéssica Elizabeth

Abstract

Burns is a form of acute skin injury caused by trauma to heat, cold, electricity, chemicals, friction, or radiation with a high incidence rate. However, burns that are not properly treated will have an impact on further problems in the future, such as the appearance of hypertrophy scar, keloid, and contractures caused issues that have an impact on decreasing the quality of life. One of the newest methods of healing burns is using the secretome from mesenchymal stem cells. One case was reported, a 47-year-old woman with second-degree burns who was given intervention in the form of secretome from Placenta Warton Jelly Mesenchymalchymal Stem Cell (SC-PWJSC). During the 20 days of the intervention, there was excellent wound healing without hypertrophy scar or keloid with significant no local or systemic side effects were found.

Dermatologic Treatments and ResearchWound Healing and TreatmentsHair Growth and DisordersMesenchymal stem cellWharton's jellyMedicineWound healingStem cellBurn injuryStem-cell therapySkin repairMuscle contractureSurgery
Citations
7
FWCI
0.94
field-weighted impact
References
31
Percentile
78%
vs. same field & year
Citations per year
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References
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On the Nature of Hypertrophic Scars and Keloids: A Review
Plastic & Reconstructive Surgery · 1999 · 814 citations
Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine
International Journal of Molecular Sciences · 2017 · 1,300 citations
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