Lipid peroxidation and antioxidant status in cigarette smokers ischemic heart disease (IHD) patients

Abstract

Methods: The study group consisted of 50 smokers and 50 healthy individuals aged between 35-65 years. During the course of study, some smokers presented with clinical signs and symptoms of ischemic heart disease. ECG of the individuals of the study group was done and accordingly they were classified as smokers with and without IHD, Lipid peroxidation, antioxidant status, Serum Total Cholesterol and its fractions, Triglyceride, HDL, LDL and VLDL were estimated. Out of the total number of smokers (n=50) involved in the study, 22 individuals presented with changes in their ECG pattern diagnostic of IHD (44% conversion rate). Most of these individuals who presented with changes in ECG pattern of IHD were chain smokers (heavy smokers) or individuals smoking for more than 30 years. All of these individuals were non-diabetic. Results: The level of Serum Cholesterol, triglycerides, VLDL, LDL, hs-CRP and MDA were found to be significantly raised in smokers while HDL cholesterol, ratio of esterified cholesterol to free cholesterol and Glutathione was significantly decreased (p