article Open AccessTop 10% cited
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation
Nature Structural & Molecular Biology · 2020 · Vol. 27(10) · pp. 959–966
Katharina Schubert✉(ETH Zurich)Evangelos D. Karousis(University of Bern)Ahmad Jomaa(ETH Zurich)Alain Scaiola(ETH Zurich)Blanca Echeverria(ETH Zurich)Lukas‐Adrian Gurzeler(University of Bern)Marc Leibundgut(ETH Zurich)Volker Thiel(University of Bern)Oliver Mühlemann(University of Bern)Nenad Ban(ETH Zurich)
SARS-CoV-2 and COVID-19 ResearchViral gastroenteritis research and epidemiologyViral Infections and Immunology ResearchTranslation (biology)Five prime untranslated regionTranslational frameshiftEIF4EEukaryotic Small Ribosomal SubunitInitiation factorCell biologyMessenger RNABiologyEukaryotic initiation factor
MeSH terms
Protein DomainsBetacoronavirusSARS-CoV-2HeLa CellsHumansModels, MolecularMutationProtein ConformationRecombinant ProteinsRNA, MessengerProtein BiosynthesisViral Nonstructural Proteins5' Untranslated RegionsCryoelectron MicroscopyRibosome Subunits, Small, Eukaryotic
Funding
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Functional Genomics Center Zurich
Citations
628
FWCI
12.27
field-weighted impact
References
42
Percentile
99%
vs. same field & year
Citations per year
Cited by
Coronavirus biology and replication: implications for SARS-CoV-2
Nature Reviews Microbiology · 2020 · 3,331 citations
References
The Phyre2 web portal for protein modeling, prediction and analysis
Nature Protocols · 2015 · 10,162 citations
Mechanisms and enzymes involved in SARS coronavirus genome expression
Journal of General Virology · 2003 · 885 citations
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
Nature Methods · 2017 · 10,267 citations
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
Nature Methods · 2017 · 8,716 citations
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