Development and standardization of novel herbal formula for the management of kidney disease

Abstract

Herbal medicine is the oldest form of health care known to mankind. It is an integral part of the development of modern civilization. Ancient literature has prescribed various herbs for the cure of kidney disease. The term Pasanabheda has been cited in the literature to identify the group of plants which have been extensively used in the indigenous system of medicine to dissolve urinary calculi and stones. Nephrotoxicity is importantly modulated as a result of biotransformation. There is a continuous search for agent that provides nephroprotection against the renal impairment for which allopathy offers no remedial measures. Hence, present study was an attempt to develop novel herbal formulation to management and treatment of kidney disease comprising alcoholic extract of Aerva javanica, Hydro alcoholic extract of Ocimum basilicum, aqueous extract of Kalanchoe pinnata. The Preformulation parameters and parameters for finished product (hard gelatin capsule) include uniformity of weight, disintegration time, moisture content, pH, phytochemical estimation were performed. Polyherbal mixtures of selected plants were screened for their nephroprotective activity. Polyherbal mixure of plant shows maximum nephroprotective activity against Vero cell line by induced toxicity with cisplatin.