A study on in vitro anti- inflammatory activity of silver nanoparticles synthesized from Dodonaea angustifolia leaf extract

Abstract

This paper presents an empirical analysis on the use of aqueous extract of Dodonaea angustifolia for the production of silver nanoparticles (AgNPs) from aqueous silver nitrate. The Dodonaea angustifolia leaf extract, AgNPs and Diclofenac sodium at different concentrations was incubated with egg and Bovine serum albumin in controlled experimental conditions and subjected to determination of absorbance to assess the anti-inflammatory property. Diclofenac sodium was used as the reference drug. The present findings exhibited a concentration dependent inhibition of protein denaturation by Dodonaea angustifolia extract and AgNPs. The effect of AgNPs was found to be high when compared with the Dodonaea angustifolia extract and near to the diclofenac sodium. From the present study it can be concluded that AgNPs possessed marked in vitro anti-inflammatory effect against the denaturation of protein.