Study on preliminary phytochemical screening and anti ulcer activity of Agaricus bisporus

Abstract

Peptic ulcer is the most prevalent gastrointestinal disease. Even though a wide range of drugs are available for the treatment of peptic ulcer, but many of these do not fulfill all the requirements and have side effects. These factors have attracted researchers to investigate the natural products which have more efficacy, less side effects and less expensive for the treatment of peptic ulcer disease. In the present study the anti-ulcer activity of Agaricus bisporus investigated in the aspirin pylorus ligated induced ulceration in rats. The administration of A. bisporus 250 mg/kg and 500 mg/kg and observed the anti ulcer activity. A. bisporus 500 mg/kg showed significant decreased the offensive factors like ulcer index and acid secretion and also reduced gastric Ph. The efficacy of Agaricus bisporus was comparable with the reference drug Ranitidine. The results of the present study reveal that the A. bisporus having efficiency in the gastro protective activity. It is recommended that the above mushroom can be further studied for their anti ulcer efficacy in human subjects.