Evaluation of anti-diabetic efficacy of the leaves and flower of Phlogacanthus thyrsiflorus Nees

Abstract

Diabetes mellitus (DM) is a metabolic disorder in which blood glucose level is abnormally high resulting from defects in insulin production, insulin action or both. The number of individual diagnosed by this disease is increasing worldwide. It is diagnosed with a global incidence of 463 million and more than 62 million individuals in India. Phlogacanthus thyrsiflorus Nees is a traditional plant with medicinal property which is used in the treatment of diabetes, wounds, whooping cough, menorrhagia, tumours and as a blood purifier. This study compares the antidiabetic property of leaves and flowers for establishing qualitative and quantitative standards on Phlogacanthus thyrsiflorus’s leaves and flowers. The antidiabetic study was done in-vivo in albino rats using streptozocin as the toxicant. The rats were treated for twenty-one days. The data obtained from the ethanolic extracts of leaves and flowers shows the effect in lowering the blood glucose level and maintains other biochemical parameters in the test group which was compared with the group treated with standard drug metformin and negative control group. The leaf and flower of Phlogacanthus thyrsiflorus produced significant antidiabetic effects in comparison to standard and diabetic control.