Combined effect of tyramine and phlorizin on isoproterenol induced myocardial infarction in wistar rats

Abstract

This study aims to investigate the combined effect of Tyramine and Phlorizin on lipid peroxides, Antioxidant enzymes and membrane bound enzymes in isoproterenol induced myocardial infarction were studied in Wistar rats. Pretreatment with Tyramine and Phlorizin at different doses of 10, 20 and 30 mg/kg to isoproterenol (85mg/kg) treated rats significantly prevented the altered lipid peroxides, antioxidant enzymes and membrane bound enzymes to near normal status. The results of our study showed that the cardio protective potential of Tyramine and phlorizin on isoproterenol induced myocardial infarction, due to its antioxidant and free radical scavenging effects, maintains the defense system against cardiac damage.