Phytochemical and toxicity studies of the leaves of Mangifera Indica, Cajanus cajan and of Piliostigma thonningii, acclimated in Benin, used against diarrheal disease

Abstract

Diarrhoeic diseases caused several million deaths in the world annually, especially in Africa. 52 billion FCFA is annual attributed to this disease in Benin. They are very little scientific workonplants which can curediarrhoeic diseases in Benin. The aim of this study is to perform phytochemical screening, toxicological study of aqueous and ethanolic extracts of Mangifera Indica, Cajanus cajan and Piliostigma thonningii leaves and the relationship between the phytochemical compositions. The leaves of this plants contained notably tannins and flavonoid which show good relationship. Aqueous and ethanolic extracts have LD50 ≥ 5000mg / kg w.b and are not toxic on shrimp larvae. Practically no significant effect was observed on rats (hematological and biochemical parameters: P>0.05). This study demonstrated relationship between the phytochemical compositions of the three plants with no toxic effect. Further antidiarrheal studies of these extracts will provide better insights on this plants and endogenous practice.