Study on Osteopotential activity of Terminalia arjuna bark extract using UMR 106 cells

Abstract

Bark extract of Terminalia arjuna (TA) possesses potent medicinal properties and therefore, used to cure various ailments in Ayurveda for over 2,500 years. We analyzed the phytochemicals contained in the methanol extract by common and available standard tests. The phytochemical screening revealed that the major bioactive components of the plants are terpenoids, polyphenols, saponins, tannins, alkaloids, flavonoids, carbohydrates, proteins, steroids and glycosides. Cytotoxicity, alkaline phosphatase activity and mineralization potential were assessed using UMR 106 cells. Increased alkaline phosphatase and calcium release were observed in TA extract compared with control. The observed osteoblastogenic induction effect of TA extract holds promise for its development as a bio supplement in bone tissue engineering research.