Phyto chemical investigation & anti-ulcer activity of Jasminum grandiflorum

Abstract

The leaves and Roots of Jasminum grandiflorum L. (Family: Oleaceae) is used in folk medicine for treating ulcerative stomatitis, skin diseases, ulcers, wounds, etc. Anti-ulcer activity of alcoholic extract of leaves and Roots of Jasminum grandiflorum L. were evaluated employing aspirin + pylorus ligation (APL) induced acute gastric ulcer models in albino rats. The effect of ethanolic extract of leaves and Roots of Jasminum grandiflorum L. (200 mg/kg, b.w., orally) on the volume of gastric juice, gastric pH, total acid, free acid and ulcer induces in the pyloric legated rats were studied for the assessment of antiulcer activity. There was a significant (P< 0.01) dose-dependent decrease in the ulcerative lesion index produced by aspirin + pylorus ligation (APL) induced acute gastric ulcer models in albino rats by leaf Extract as compared to the standard drug pantoprazole (20 mg/kg, b.w. orally). The reduction in gastric fluid volume, free acid, total acid and an increase in the pH of the gastric fluid in APL rats proved the antisecretory and potential antiulcer activity of leaves of Jasminum grandiflorum.