A review on extended release matrix tablet for overactive bladder

Abstract

Darifenacin is extended for treatment of urge incontinence or increased urinary frequency that creates urgency in patients with overactive bladder and thus once a day extended release tablet eliminates the multiple dosing and the half life of drug is 13 hours. Extended release dosage forms release drug slowly, so that plasma concentrations are maintained at a therapeutic level for a prolonged period of time as usually between 8 and 24 hours. By incorporating the dose for 24hrs into one tablet from which the drug is slowly released, peaks of high plasma concentration and troughs of low plasma concentrations can be prevented. Avoids the high blood concentration. Maintain therapeutic concentration over prolonged periods. Film coating of tablet will mask the bitter taste of drug and also protect from moisture during storage.