Experimental evaluation of anti-inflammatory activity of Cinnamomum zeylanicum oil in male wistar rats

Abstract

The present study was planned to evaluate in vivo anti-inflammatory activity of cinnamon oil (Cinnamomum zeylanicum) following single dose oral administration (50, 100 and 200 mg/kg) in male wistar rats. The in-vivo anti-inflammatory assay of cinnamon oil was carried out using carrageenan induced paw edema model in rats. Indomethacin was administared @ 10 mg/kg in standard drug control rats. Rats of control groups were kept untreated and other groups were treated with cinnamon oil @ 50, 100 and 200 mg/kg b.wt., respectively. The anti-inflammatory effect of cinnamon oil was highest at 3h (30.58%) at the dose of 200 mg/kg. It was lower than anti-inflammatory effect of standard drug indomethacin at 3h (42.99%). Cinnamon oil showed dose dependent anti-inflammatory activity in wistar rats.