Anticonvulsants and anti-nociceptive effect of ziziphus xylopyrus wild (Rhamnaceae) stem bark ethanolic extract

Abstract

The available synthetic analgesic and anti-nociceptive drugs possess several health problem during their clinical use. To avoid these ill effect on health, it is necessary to search or develop a more effective drug with fewer side effects. Hence, the present investigation was carried out to test anticonvulsant effect and anti-nociceptive effect Ziziphus Xylopyrus (Retz.) Willd bark ethanolic extract. The anticonvulsant effect was done using using Maximum Electo Shock (MES) induced convulsion in rats. The extract (200 mg/kg p.o) significantly increased the threshold of MES-induces convulsion in rat compared with the control group. Which showed 83.34% protection in rat. The anti-nociceptive effect was done using tail flicl method. A maximum effect was 10.9 sec at 120 min post treatment with 200mg/kg p.o. Ziziphus xylopyrus (Retz.) Willd is effcetive. Where in the vehicle treat control group the reaction was 4.8 sec. Thus, Ziziphus Xylopyrus (Retz.) Willd bark is very useful medicinal plants besides its several economical use. The ethanolic extract is useful for epilepsy and pain as suggested dose.