Haplotype: Alleles moving together

Abstract

Haplotype is a set of single nucleotide polymorphisms (SNPs) on a single chromatid that are statistically associated. Combination of alleles of closely linked loci, those are found in a single chromosome and tend to be inherited together. Haplotype analysis is useful in identifying recombination events. The study of haplotypes within genes, which is also of great current interest, provides the opportunity to discover reliable markers of various phenotypes. Haplotype trees provide methods for examining the phylogeny of individuals based on their haplotypes and also provide methods for understanding molecular (genomic) natural selection. These trees can be created for one species or can be created to represent inter-species haplotypic phylogenies.