Grinding: A novel method for synthesis of potential antifungal pyrazoles

Abstract

A benign, rapid and solvent free synthesis of pyrazoles have been done by grinding techniques by using substituted benzaldehyde, malanonitrile and 2,4-dinitrophenyl hydrazine and comparison has been done with conventional method in which solvent is used. Special features of grinding techniques involve ecofriendly, non hazardous, excellent yield and short time reaction. The synthesized compounds have been screened for their antifungal activity against Asperillus niger and Rhizoctonia solani. These synthesized compounds were characterized by IR, 1HNMR and melting point.