Screening and extraction of biofilm inhibitors from Lactobacillus isolated from fruit extracts against Vibrio cholerae

Abstract

Bacteria being resistant to various antimicrobial treatments, due to its ability to form biofilm, it can survive harsh conditions and withstand the host’s immune system. This has drawn considerable interest from researchers to identify new therapy options to treat biofilm-associated infections. The need for development of antibiofilm agents that are nontoxic is increasing rapidly. The new antibiofilm agents have the potential to disperse bacterial biofilms in vivo and could positively impact human medicine in the future. The current study deals with the effect of Lactobacillus isolate which inhibit the biofilm formation of Vibrio Cholerae by producing a potent inhibitor. The organism was identified and screened for the production of bioactive compounds. Our results revealed the inhibition of biofilms up to 80%. Antibiofilm agents that can both disseminate and destroy biofilm bacteria could have some useful applications but remain rare.