Investigation of anti-diabetic potential of Jasad bhasma against streptozotocin induced diabetes in rat

Abstract

The present study was undertaken to prepare ayurvedic preparation Jasad bhasma and evaluate its effect on streptozotocin induced diabetic rats along with their associated diabetic complications. Jasad bhasma was prepared as per the standard reference. The hypoglycemic effect of the Jasad bhasma was evaluated in normal rats by oral glucose tolerance. Jasad bhasma (100 mg/kg), (200 mg/kg) and Glibenclamide (10 mg/kg) caused 25.03%, 30.47% and 48.71% reduction (P<0.001) in serum glucose levels respectively at 6 hours after glucose load. Diabetic rats treated with Jasad bhasma (100 mg/kg), (200 mg/kg) and Glibenclamide showed a significant antihyperglycemic effect with a reduction of 46.95%, 47.08% and 49.96% serum glucose level respectively. Both doses were efficient in reducing serum triglycerides, cholesterol, low density lipoprotein and very low density lipoprotein to normal values and there was a marked rise in high density lipoprotein level as compared to diabetic control group. Hence it can be effectively employed for the control of diabetes and its associated complications.