A review on in situ gel therapy for epilepsy via nasal route

Abstract

The currently available antiepileptic drugs are typically administered via oral route which commonly exhibit high systemic distribution into non-targeted tissues, leading to peripheral effects and limited brain uptake. In order to improve the efficacy and tolerability of the antiepileptic drug therapy, alternative administration strategies have been investigated. Olfactory epithelium situated on the roof of nasal cavity is said to deliver nasally administered medications directly to brain. Nasal in situ gel in which liquid solution of drug formulation get converted into semisolid when it comes in contact with nasal mucosa. In situ gelling has many approaches like temperature induced, pH induced, osmotically induced, ion cross linking etc. The development of nasal in situ gel leads to various advantages like decrease frequency of drug administration, low dose requirement, increase patient compliance.