Hepatoprotective activity of herbadict tablets on alcohol-induced mortality and liver lesions in mice

Abstract

Objective of the current research is to study the possible protective effects of Herbadict tablet a Polyherbal Ayurvedic product against alcohol-induced mortality and liver lesions in mice. Healthy Female Swiss albino mice were divided into six groups containing 8 animals each. Herbadict tablet was suspended in 0.5% carboxy methyl cellulose (CMC) and administered at two doses i.e.30mg/kg and 100 mg/kg body weight. Vehicle control, positive control and reference control (Silymarin) were used for comparison. Alcoholic intoxication was induced using ethanol. Treatment with Herbadict significantly (p<0.01) decreased SGOT, SGPT and g-GT at 100 mg/kg when compared to the vehicle treated alcohol intoxicated group. A dose dependant significant decrease in total bilirubin was observed at 30 and 100 mg/kg of Herbadict when compared to vehicle treated alcohol intoxicated group. Treatment with Herbadict at 30 and 100 mg/kg p.o. showed hepatoprotective effect against alcohol induced damage in mice model