Effect on the body weight, organ weight and haematology during sub-chronic lantadene toxicity and its amelioration with Berberis lycium and Picrorhiza kurroa in guinea pigs

Abstract

Background: The objective of this study was to investigate the ameliorative effect of Berberis lycium and Picrorhiza kurroa on lantadene-induced sub-chronic toxicity in Guinea pigs. Method: Total 42 Guinea pigs of either sex were divided into 7 groups: Group-C served as control, Group- L (Lantadene @ 24mg/kg bw), Group-L+B1 (B. lycium @ 100 mg/kg bw), Group- L+B2 (B. lycium @ 200 mg/kg bw), Group- L+P1 (P. kurroa @ 100 mg/kg bw), Group- L+P2 (P. kurroa @ 200 mg/kg bw), Group- L+ S (Silymarin @ 100 mg/kg bw). Each group except control received oral dose of lantadene (24 mg/kg bw) daily. Ameliorative groups were treated with daily oral dose of ameliorative plant extract one hour after lantadene treatment.Results: Significant decrease in weekly body weights, Hb (gm/dl), PCV% and significant increase in absolute and relative weight of liver were recorded.