Ameliorative effect of Andrographis paniculata on hematobiochemical parameters in Escherichia coli induced broilers

Abstract

One hundred, day old broiler chicks were randomly divided into four equal groups. From day 0 birds from groups III and IV fed with Andrographis paniculata @ 5 gm/kg of feed. However, on day 8, each bird from group II and IV were challenged with single oral dose of E. coli broth culture @ 0.2 ml (1X 109 cfu/mL). Hematological, biochemical and histopathological parameters were recorded on 14th, 28th and 35th day of experiment. The significantly lower Hb, PCV and TEC were observed in group II on 14th, 28th and 35th day while significant increase was observed in group IV. Differences of MCV and MCH differed significantly on 14th day. The average mean TLC on 14th, 28th and 35th days of experiment were found to be significantly increased in group II. Significantly increased absolute heterophil count and significantly decreased absolute lymphocyte count was observed in group II while group IV showed significant decrease in absolute heterophil count and increase in absolute lymphocyte count on 28th and 35th day. The serum total protein and albumin was significantly increased in group IV compared to group II on 14th, 28th and 35th day. Serum globulin in group II differ significantly on 28th and 35th day among different groups. Serum AST and ALT values were significantly increased (P