Ameliorating effect of curcumin against fipronil induced subacute toxicity in rats

Abstract

Fipronil is a class of phenyl pyrazole pesticides used for the control of a wide range of agricultural, public health and veterinary pests. Curcumin, a polyphenolic compound obtained from turmeric (Curcuma longa) possesses a number of pharmacological activities. Present study was conducted to evaluate the ameliorative effect of curcumin against fipronil induced toxicity in rats. Rats were divided in to three groups, having six animals in each group. Group I was treated as control and group II and III received, fipronil (10 mg/kg b.wt) and fipronil + curcumin (10mg/kg b.wt +100mg/kg b.wt) respectively orally daily for 28 days. The results revealed that fipronil caused significant reduction in body weight of rats after 28 days of exposure compared to control group, which may be due to oxidative stress by induced by fipronil. Fipronil also significantly increased the serum level of AST, ALT, ALP LDH, BUN and creatinine on after 28 days of exposure indicated liver and kidney damage by fipronil. However supplementation of curcumin mitigated the adverse effects of fipronil by reducing the elevated level of serum biochemical parameters.