Hepatoprotective potentials of Sida corymbosa (broom weed) ethanolic leaf extract against carbon tetrachloride (ccl4)-induced hepatotoxicity on male albino wistar rats

Abstract

This study aimed at evaluating the hepatoprotective potentials of Sida corymbosa ethanolic leaf extract against carbon tetrachloride (CCL4)-induced hepatotoxicity in male Albino Wistar rats. Determination of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were done spectrophotometrically. The acute toxicity study carried out suggests that the extract may have an LD50 above 5000 mg/kgbw. serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase levels decreased significantly (P<0.05) in rats given the extract at 5000, 3000, and 1000mg/kgbw and injected carbon tetrachloride when compared to those injected carbon tetrachloride only. This suggests protection of the liver of rats by the extract against carbon tetrachloride -induced toxicity. Histological examination confirmed the results of the biochemical findings. Sida corymbosa ethanolic leaf extract may therefore protect the liver of male Albino Wistar rats against carbon tetrachloride and may be dependent on dosage and time.