A comparative study of Atracurium and Cisatracurium for assessment of intubating conditions

Abstract

Introduction: Muscle relaxation is used to facilitate endotracheal intubation, to provide surgical relaxation. While selecting neuromuscular agent for tracheal intubation main aim is to select agent with better intubating conditions, longer duration of action, better hemodynamic stability and good spontaneous reversal. Materials and methods: This study is designed as randomized controlled clinical trial to compare between atracurium and Cisatracurium regarding onset, duration of action and intubating conditions. Group A received 2×ED95 dose (0.5mg/kg) of Atracurium, group C received 4×ED95 dose (0.2mg/kg) of Cisatracurium. Endotracheal intubation was done by using Train-Of-Four monitor, at TOF score 0. Results: In our study, difference in mean Intubating condition score was not statistically significant. Mean onset time for group A was 3.7 minutes which was faster as compared to group C which was 6.04 minutes and mean duration of action for group C was 59.43 minutes which was significantly more compared to group A 38.93 minutes. Conclusion: From above observations we conclude that, both the drugs provide comparable intubating condition. Atracurium 2×ED95 dose has faster onset & shorter duration of muscle relaxation than Cisatracurium 4×ED95 dose.