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Inferred duration of infectious period of SARS-CoV-2: rapid scoping review and analysis of available evidence for asymptomatic and symptomatic COVID-19 cases

BMJ Open · 2020 · Vol. 10(8) · pp. e039856–e039856

Andrew W. Byrne✉(Government of Ireland)David M. McEvoy(University College Dublin)Áine B. Collins(University College Dublin)Kevin Hunt(University College Dublin)Miriam Casey-Bryars(University College Dublin)Ann Barber(University College Dublin)Francis Butler(University College Dublin)John Griffin(Government of Ireland)Elizabeth Lane(University College Dublin)Conor G. McAloon(University College Dublin)Kirsty O’Brien(Health Information and Quality Authority)Patrick Wall(University College Dublin)Kieran Walsh(Health Information and Quality Authority)Simon J. More(University College Dublin)

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Abstract

There are limitations of inferring infectiousness from repeated diagnosis, viral loads and viral replication data alone and also potential patient recall bias relevant to estimating exposure and symptom onset times. Despite this, available data provide a preliminary evidence base to inform models of central tendency for key parameters and variation for exploring parameter space and sensitivity analysis.

COVID-19 Clinical Research Studies SARS-CoV-2 and COVID-19 Research COVID-19 epidemiological studiesMedicineAsymptomaticCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Viral loadPediatricsInfectious disease (medical specialty)Internal medicineVirologyVirus

MeSH terms

BetacoronavirusCOVID-19SARS-CoV-2AdultChildCommunicable DiseasesHospitalizationHumansPneumonia, ViralGlobal HealthPolymerase Chain ReactionCoronavirus InfectionsViral LoadPandemics

Citations

429

FWCI

9.12

field-weighted impact

References

102

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98%

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References