Platelet rich fibrin in regenerative endodontics: An update

Abstract

Endodontic therapy has enabled the rehabilitation of numerous teeth over the years. The revitalization of the teeth or replacement of the diseased and nonvital pulp with healthy pulp tissue remains as the most desired outcome of endodontic treatment. Regenerative endodontic procedures require the use of appropriate scaffolds to provide a spatially correct position of cell location, regulate differentiation, proliferation, or metabolism of the stem cells. Platelet-rich fibrin is one such scaffold which is currently gaining popularity in the field of regenerative endodontics. To ensure a successful and predictable outcome of regenerative endodontic procedure, it is of vital importance to have thorough and precise knowledge about the scaffolds used. This review provides an insight and an update about the use of platelet-rich fibrin in regenerative endodontic procedures, its benefits and limitations.