Study of intavenous granisetron on haemodynamic changes and motor and sensory blockade in spinal anesthesia with hyperbaric bupivacaine in patient undergoing infraumblical surgery

Abstract

Objective: The aim of this study is to examine the effects of granisetron on the sensory and motor block and haemodynamic changes resulting from subarachnoid block using hyperbaric bupivacaine. Methods: Forty ASA I and II adult patients undergoing infraumblical surgery under spinal anesthesia were included in this prospective, randomised, double blind study. They wrere randomly divided into two groups.Using computer generated random numbers, patients were allocated to one of two groups: Control Group:Patients of this group received normal saline. GranisetronGroup:Patients of this group received 1mg Granisetron. Patients of both groups received heavy 0.5% Bupivacaine intrathecally. Result: All the demographic parameters were comparable.19 patients (67.8%) in saline group while 13 patients (46.4%) in granisetron group had hypotension which was treated with IV ephedrine. Saline group had more than three episodes of hypotension while none of the patients in granisetron group had hypotensive episodes more than two.The maximum cephalad spread of sensory block was similar (P = 0.13).TPatients who received granisetron had significantly faster sensory regression times by two segments from T12 - S1. However motor regression is similar in both group. There were no significant differences between the two groups in haemodynamic variables. Conclusion: IV administration of granisetron, in a dose of 1 mg, before intrathecal bupivacaine results in a faster recovery of sensory block in adult patients. There is also less incidence of hypotension in Granisetron group.