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The SARS-CoV-2 main protease as drug target

Bioorganic & Medicinal Chemistry Letters · 2020 · Vol. 30(17) · pp. 127377–127377

Sven Ullrich(Australian National University)Christoph Nitsche✉(Australian National University)

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SARS-CoV-2 and COVID-19 Research Computational Drug Discovery Methods COVID-19 Clinical Research StudiesProteasesProteaseDrug discoveryPeptidomimeticVirologyCoronavirusDrugChemistrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Drug development

MeSH terms

BetacoronavirusSARS-CoV-2Coronavirus 3C ProteasesAmino Acid SequenceAnimalsAntiviral AgentsCell LineCysteine EndopeptidasesHumansSubstrate SpecificityCysteine Proteinase InhibitorsViral Nonstructural ProteinsDrug DiscoveryPeptidomimetics

Funding

Australian Research Council

Citations

785

FWCI

15.74

field-weighted impact

References

114

Percentile

99%

vs. same field & year

Citations per year

References

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Nature Reviews Microbiology · 2009 · 1,765 citations

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An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

Journal of Medicinal Chemistry · 2016 · 840 citations

Origin and evolution of pathogenic coronaviruses

Nature Reviews Microbiology · 2018 · 5,807 citations

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