Role of bone turnover marker-bone specific alkaline phosphatase evaluation in monitoring healing of tibial shaft fractures managed by closed reduction

Abstract

Methodology: A study to evaluate the changes in BAP levels during healing of isolated closed tibial shaft fracture was conducted by including 25 healthy adults of age 18 to 45 years. Normal fracture healing time was defined to be 6 months in a tibial shaft fracture. The patients having any systemic condition, disease, and/or drug intake affecting bone turnover were excluded. All the fractures were treated with closed reduction. Follow up was done at every 4 weeks till 6 months of injury to look for clinic-radiological signs of fracture union. Biochemical monitoring was done at time of injury, 4, 8 and 12 weeks. BAP was measured using enzyme immunoassay.