Development and characterization of polymeric microparticles containing Murraya koenigii leaves extract for management of diabetes mellitus

Abstract

Diabetes mellitus is a heterogeneous metabolic disorder characterized by common feature of chronic hyperglycemia with disturbance of carbohydrate, fat and protein metabolism. There are many undesired effects related with the synthetic drug molecules and in case of diabetes there is drug regimen which means more synthetic drug and more associated side effects. Current work is based on the extraction of roots of Glycyrrhiza glabra Linn. Which is of natural origin; this will help to get rid of side effects and after that the problem was dosing frequency which is again a drawback of diabetes treatment. We had selected the particulate carrier system for the drug release modification. Characterization and performance evaluation of particulate system loaded with herbal plant extract of the Glycyrrhiza glabra roots was done. Solid lipid nanoparticles was formulated and characterized for the particle size, shape and its distribution, percentage drug entrapment and In-vitro drug release profile along with the stability studies. In-vivo tissue distribution studies on albino rats suggested the accumulation of formulations in the different organs. These results suggest that the solid lipid nanoparticles are not only effective in rapid attainment of high drug concentration in body and also maintain the same over prolonged period of time.