Vitamin d and parathyroid hormone levels and their association with insulin resistance in type 2 diabetes subjects

Abstract

Vitamin D deficiency is associated with metabolic diseases like Type-2 diabetes mellitus, obesity and insulin resistance. Previous studies have evaluated the effects of vitamin D and parathyroid hormone (PTH) separately in isolation rather than studying the combined effects of both hormones together as a reflection of the status of the PTH-Vitamin D axis. Low vitamin D coupled with increased PTH may be a better indicator, which is the novelty of the present study. A total of 151 Type 2 diabetic subjects attending the outpatient clinics of endocrinology department of MMC&RI, Mysore, were chosen for the study. Vitamin D, PTH, calcitonin and Insulin levels were analysed using chemiluminescence Immuno assay techniques. Comparison was made between normal (vitamin D >20ng/ml) and vitamin D deficient (vitamin D