Non-neoplastic urothelial lesions and mimickers of malignancy: Take Cognizance - Avoid negligence

Abstract

Background: The differential diagnosis of urothelial neoplasms also includes several histologic mimics, the importance of which cannot be overemphasized since misdiagnosis could have serious clinical and prognostic implications. Aims: To study the variety of non-neoplastic lesions of the urothelial tract that could potentially be confused with urothelial neoplasms. Material and Methods: A retrospective and prospective study of five years duration was done at a tertiary care hospital including 55 cases of non-neoplastic urothelial lesions. Results were analysed using SPSS22. Results: Out of 43.62% of cases clinically suspicious for malignancy, majority (18.18%) were florid Proliferation of von brunn nests. Out of 56.3% cases clinically non-suspicious for malignancy majority were nonspecific cystitis (12.72%). The nonneoplastic lesions were more common in males (83.3%). The mean age was 45.6 yrs. Conclusions: Diagnostic awareness of salient histomorphologic features of the benign mimickers of urothelial neoplasms is critical to avoid rendering false positive diagnoses of malignancy.