Determine of S100A8 level in patients of chronic spontaneous uritcaria

Abstract

Introduction: Chronic spontaneous uritcaria (CSU) is characterized by the spontaneous appearance of transient itchy wheals, angioedema or both, for at least 6 weeks. The present study was conducted to determine level of S100A8 in patients of chronic spontaneous uritcaria. Materials & Methods: The present study was conducted on 82 cases (Group I) of chronic spontaneous uritcaria of both genders. Equal number of healthy subjects (Group II) was also taken. CSU was diagnosed according to the EAACI/GA2 LEN/ EDF/WAO guidelines. Plasma levels of S100A8 were assessed using human enzyme linked immunosorbent assay (ELISA) kit. Results: There were 34 male and 48 female in group I and 42 males and 40 female in group II. Mean age in group I was 27.1 years and in group II was 29.2 years. Basophil count was 0.21% in group I and 0.45% in group II. Eosinophil count was 1.62 % in group I and 2.15% in group II. The mean S100A8 level in group I was 2415.6 pg/ml and in group II was 1380.9 pg/ml. Conclusion: Authors found that Plasma S100A8 level was higher in CSU patients. It may serve as biomarkers of CSU.