article Open AccessTop 1% cited
Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19
Circulation Research · 2020 · Vol. 126(12) · pp. 1671–1681
Peng Zhang✉(Wuhan University)Lihua Zhu(Wuhan University)Jingjing Cai(Central South University)Fang LeiJuan‐Juan Qin(Wuhan University)Jing Xie(Wuhan University)Ye-Mao Liu(Wuhan University)Yan-Ci Zhao(Wuhan University)Xuewei Huang(Wuhan University)Lijin Lin(Wuhan University)Xia MengMingming Chen(Wuhan University)Xu Cheng(Wuhan University)Xiao Zhang(Wuhan University)Deliang Guo(Wuhan University)Yuanyuan Peng(Wuhan University)Yan‐Xiao Ji(Wuhan University)Jing ChenZhi‐Gang She(Wuhan University)Yibin Wang(University of California, Los Angeles)Qingbo Xu(Queen Mary University of London)Renfu TanHaitao Wang(Wuhan University)Jun Lin(Wuhan University)Pengcheng Luo(Tongren Hospital)Shouzhi Fu(Tongren Hospital)Hongbin Cai(Soochow University)Ping Ye(Central Hospital of Wuhan)Bing Xiao(Xiaogan First People's Hospital)Weiming Mao(Huanggang Central Hospital)Li Liu(Liuzhou General Hospital)Youqin Yan(Wuhan No. 7 Hospital)Mingyu Liu(Soochow University)Manhua Chen(Wuhan University)Xiao‐Jing Zhang(Wuhan University)Xinghuan Wang(Wuhan University)Rhian M. Touyz(University of Glasgow)Jiahong Xia(Huazhong University of Science and Technology)Binghong Zhang(Wuhan University)Xiaodong Huang(Wuhan University)Yufeng Yuan(Wuhan University)Rohit Loomba(University of California San Diego)Peter P. Liu(University of Ottawa)Hongliang Li(Wuhan University)
Abstract
Among hospitalized patients with COVID-19 and coexisting hypertension, inpatient use of ACEI/ARB was associated with lower risk of all-cause mortality compared with ACEI/ARB nonusers. While study interpretation needs to consider the potential for residual confounders, it is unlikely that in-hospital use of ACEI/ARB was associated with an increased mortality risk.
COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19COVID-19 and Mental HealthMedicineInterquartile rangeHazard ratioInternal medicineAngiotensin-converting enzymePropensity score matchingProportional hazards modelRetrospective cohort studyConfidence intervalBlood pressure
MeSH terms
COVID-19AgedAngiotensin-Converting Enzyme InhibitorsFemaleHumansHypertensionInpatientsMaleMiddle AgedPneumonia, ViralHospital MortalityCoronavirus InfectionsAngiotensin Receptor AntagonistsPandemics
Funding
- National Natural Science Foundation of China
Citations
1,181
FWCI
28.47
field-weighted impact
References
32
Percentile
100%
vs. same field & year
Citations per year
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