article Open AccessTop 1% cited
Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
British Journal of Cancer · 2020 · Vol. 122(11) · pp. 1630–1637
David S. Hong✉(The University of Texas MD Anderson Cancer Center)Yoon‐Koo Kang(Asan Medical Center)Mitesh J. Borad(Mayo Clinic in Arizona)Jasgit C. Sachdev(Scottsdale Research Institute (United States))Samuel Ejadi(University of California, Irvine Medical Center)Ho Yeong Lim(Samsung Medical Center)Andrew Brenner(The University of Texas Health Science Center at San Antonio)Keunchil Park(Samsung Medical Center)Jae‐Lyun Lee(Asan Medical Center)Tae‐You Kim(Seoul National University Hospital)SangJoon Shin(Severance Hospital)Carlos Becerra(Texas Oncology)Gerald S. Falchook(Sarah Cannon)Jay Stoudemire(Mirna Therapeutics (United States))Desiree Martin(Mirna Therapeutics (United States))Kevin Kelnar(Mirna Therapeutics (United States))Heidi J. Peltier(Mirna Therapeutics (United States))Vinícius Bonato(Mirna Therapeutics (United States))Andreas G. Bader(Mirna Therapeutics (United States))Stephen M. Smith(Mirna Therapeutics (United States))Sinil Kim(Mirna Therapeutics (United States))Vincent O’Neill(Mirna Therapeutics (United States))Muhammad Shaalan Beg(The University of Texas Southwestern Medical Center)
Abstract
NCT01829971.
MicroRNA in disease regulationCircular RNAs in diseasesRNA Interference and Gene DeliveryMedicineChillsAdverse effectInternal medicineNauseaDexamethasonePremedicationCancerGastroenterologyOncology
MeSH terms
AdultAgedAged, 80 and overAntineoplastic AgentsFemaleHumansLiposomesMaleMiddle AgedNeoplasmsMaximum Tolerated DoseMicroRNAsNanoparticles
Funding
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
Citations
864
FWCI
35.59
field-weighted impact
References
51
Percentile
100%
vs. same field & year
Citations per year
Cited by
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References
MicroRNAs
Cell · 2004 · 34,668 citations
Oncomirs — microRNAs with a role in cancer
Nature reviews. Cancer · 2006 · 7,016 citations
miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells
Cancer Letters · 2008 · 429 citations
MicroRNA signatures in human cancers
Nature reviews. Cancer · 2006 · 7,589 citations
The miR-34 family in cancer and apoptosis
Cell Death and Differentiation · 2009 · 1,232 citations
p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
Current Biology · 2007 · 1,109 citations
Immune Checkpoint Blockade in Cancer Therapy
Journal of Clinical Oncology · 2015 · 2,706 citations
Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria
Clinical Cancer Research · 2009 · 3,204 citations
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